{Reference Type}: Journal Article
{Author}: Kobayashi, Donald Y.; Crouch, Jo Anne
{Year}: 2009
{Title}: Bacterial/Fungal Interactions: From Pathogens to Mutualistic Endosymbionts
{Tag}: 0
{Star}: 0
{Journal}: ANNUAL REVIEW OF PHYTOPATHOLOGY
{Volume}: 47
{Pages}: 63-82
{ISBN/ISSN}: 0066-4286
{Keywords}: ARBUSCULAR MYCORRHIZAL FUNGI; BROWN BLOTCH DISEASE; PSEUDOMONAS-FLUORESCENS PF-5; CANDIDATUS GLOMERIBACTER GIGASPORARUM; BIOLOGICAL-CONTROL ACTIVITY; MUSHROOM AGARICUS-BISPORUS; SUGAR-BEET RHIZOSPHERE; ENZYMOGENES STRAIN C3; SUMMER PATCH DISEASE; III SECRETION SYSTEM; intracellular; biological control; bacterial diseases; endosymbiosis; antibiosis
{Abstract}: A fundamental issue in biology is the question of how bacteria initiate and maintain pathogenic relationships with eukaryotic hosts. Despite billions of years of coexistence, far less is known about bacterial/fungal interactions than the equivalent associations formed by either of these types of microorganisms with higher eukaryotes. This review highlights recent research advances in the field of bacterial/fungal interactions, and provides examples of the various forms such interactions may assume, ranging from simple antagonism and parasitism to more intimate associations of pathogenesis and endosymbiosis. Information derived from the associations of bacteria and fungi in the context of natural and agronomic ecosystems is emphasized, including interactions observed from biological control systems, endosymbiotic relationships, diseases of cultivated mushrooms, and model systems that expand our understanding of human disease. The benefits of studying these systems at the molecular level are also emphasized.
{Author Address}: Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, New Brunswick, NJ 08901 USA; Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, New Brunswick, NJ 08901 USA
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: USA

{Reference Type}: Journal Article
{Author}: Kubo, E.; Yoshikawa, N.; Kunitomo, M.; Kagota, S.; Shinozuka, K.; Nakamura, K.
{Year}: 2010
{Title}: Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20944118&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Anticancer Res
{Volume}: 30
{Issue}: 9
{Pages}: 3429-33
{Date Displayed}: 2010 Sep
{Date}: 2010-09-01
{Type of Work}: Journal Article
{Accession Number}: 20944118
{Keywords}: Animals; Antineoplastic Agents/*pharmacology; Cordyceps/*chemistry; Female; Hepatocyte Growth Factor; Liver Neoplasms/*drug therapy/*secondary; Melanoma, Experimental/*secondary; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness/*pathology
{Abstract}: We investigated the anti-metastatic activity of a water extract of Cordyceps sinensis (WECS) using a model of mice injected with B16-F0 mouse melanoma cells into the spleen. WECS administered intraperitoneally reduced the number of metastatic surface nodules of B16-F0 cells in the liver of C57BL/6Cr mice in a dose-dependent manner, and significantly prolonged their survival. To identify the mechanism of the anti-metastatic effect of WECS, we examined its effects on hepatocyte growth factor (HGF)-accelerated invasion of B16-F0 cells using a chemo-invasion assay in vitro. As a result, WECS reduced HGF-accelerated B16-F0 cell invasion in a concentration-dependent manner. These findings suggest that WECS exerts an anti-metastatic action, in part by inhibiting the HGF-accelerated   tumor invasiveness of mouse melanoma cells.
{Author Address}: Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and Institute for Biosciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan.
{Language}: eng

{Reference Type}: Journal Article
{Author}: Rolland, D.; Raharijaona, M.; Barbarat, A.; Houlgatte, R.; Thieblemont, C.
{Year}: 2010
{Title}: Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity   to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21036708&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Anticancer Res
{Volume}: 30
{Issue}: 10
{Pages}: 3951-7
{Date Displayed}: 2010 Oct
{Date}: 2010-10-01
{Type of Work}: Journal Article; Research Support, Non-U.S. Gov't
{Accession Number}: 21036708
{Keywords}: Active Transport, Cell Nucleus/drug effects; Antineoplastic Agents/*pharmacology; Antineoplastic Combined Chemotherapy Protocols/*pharmacology; Boronic Acids/administration & dosage/pharmacology; Cell Growth Processes/drug effects; Cell Line, Tumor; Cisplatin/administration & dosage/pharmacology; Cytarabine/administration & dosage/pharmacology; Deoxycytidine/administration & dosage/analogs & derivatives/pharmacology; Doxorubicin/administration & dosage/pharmacology; Drug Screening Assays, Antitumor; Glutathione S-Transferase pi/*antagonists & inhibitors/metabolism; Humans; Lectins/administration & dosage/pharmacology; Lymphoma, Mantle-Cell/*drug therapy/*enzymology/pathology; Pyrazines/administration & dosage/pharmacology
{Abstract}: PURPOSE: Mantle cell lymphoma (MCL) is a chemoresistant lymphoma overexpressing the class pi glutathione-S-transferase (GST-pi). The nuclear localisation of GST-pi is induced by chemotherapy and is correlated to cell resistance. In this study, the effect of the Agaricus bisporus lectin (ABL), a GST-pi nuclear transfer inhibitor, on the chemosensitivity of MCL cells was investigated. METHODS: The proliferation of three MCL cell lines was evaluated in the presence   of doxorubicin (DOX), cisplatin (CDDP), cytarabine (Ara-C), gemcitabine (GEM) or   bortezomib with or without ABL pre-treatment. RESULTS: The cytotoxic activities of CDDP, Ara-C, GEM and bortezomib were increased in all cell lines. The DOX cytotoxic activity was enhanced in two of three cell lines. The inhibition of GST-pi nuclear transfer led to the potentialisation of all drug combinations. CONCLUSION: The inhibition of the nuclear transfer of GST-pi increases the MCL sensitivity to DOX, CDDP, Ara-C, GEM and bortezomib, alone or in combination.
{Author Address}: INSERM U836 equipe 7, Grenoble, France.
{Language}: eng

{Reference Type}: Journal Article
{Author}: Yoshikawa, N.; Kunitomo, M.; Kagota, S.; Shinozuka, K.; Nakamura, K.
{Year}: 2009
{Title}: Inhibitory effect of cordycepin on hematogenic metastasis of B16-F1 mouse melanoma cells accelerated by adenosine-5'-diphosphate
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19846919&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Anticancer Res
{Volume}: 29
{Issue}: 10
{Pages}: 3857-60
{Date Displayed}: 2009 Oct
{Date}: 2009-10-01
{Type of Work}: Journal Article
{Accession Number}: 19846919
{Keywords}: Adenosine Diphosphate/*pharmacology; Animals; Antineoplastic Agents/*pharmacology; Deoxyadenosines/*pharmacology; Dose-Response Relationship, Drug; Female; Lung Neoplasms/blood/*prevention & control/*secondary; Melanoma, Experimental/*blood/*drug therapy/secondary; Mice; Mice, Inbred C57BL; Platelet Aggregation/drug effects; Specific Pathogen-Free Organisms
{Abstract}: Platelet aggregation induced by cancer cells is an indispensable step for hematogenic metastasis. In these studies, we investigated whether platelet aggregation accelerates hematogenic metastasis of cancer cells in mice and the effect of cordycepin (3'-deoxyadenosine), a component of Cordyceps sinensis, on hematogenic metastasis accelerated by adenosine-5'-diphosphate (ADP). ADP significantly increased the number of metastatic lung nodules in mice injected intravenously with B16-F1 mouse melanoma cells (B16-F1 cells) in a dose-dependent manner and cordycepin significantly reduced the number of metastatic nodules of B16-F1 cells formed in the lung accelerated by ADP injected simultaneously with B16-F1 cells. These results suggest that ADP accelerated hematogenic metastasis and cordycepin has an inhibitory effect on hematogenic metastasis of B16-F1 melanoma cells via blocking of ADP-induced platelet aggregation in vivo.
{Author Address}: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's   University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan.
{Language}: eng