{Reference Type}: Journal Article
{Author}: Yu, Chen-Huan; Dai, Xiao-Yan; Chen, Qin; Zang, Jia-Na; Deng, Li-Li; Liu, Yue-Huan; Ying, Hua-Zhong
{Year}: 2013
{Title}: Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats
{URL}: http://www.sciencedirect.com/science/article/pii/S0144861713000106
{Tag}: 0
{Star}: 0
{Journal}: Carbohydrate Polymers
{Volume}: 94
{Issue}: 1
{Pages}: 56-62
{Date Displayed}: 2013/4/15/
{Alternate Title}: Carbohydrate Polymers
{ISBN/ISSN}: 0144-8617
{Keywords}: Characterization; Hyperlipidemia; Peroxisome proliferator-activated receptor; Lipoprotein lipase
{Abstract}: Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.

{Reference Type}: Journal Article
{Author}: Li, Xiaoyu; Wang, Zhenyu; Wang, Lu
{Year}: 2013
{Title}: Polysaccharide of Hohenbuehelia serotina as a defense against damage by whole-body gamma irradiation of mice
{URL}: http://www.sciencedirect.com/science/article/pii/S0144861713001537
{Tag}: 0
{Star}: 0
{Journal}: Carbohydrate Polymers
{Volume}: 94
{Issue}: 2
{Pages}: 829-835
{Date Displayed}: 2013/5/15/
{Alternate Title}: Carbohydrate Polymers
{ISBN/ISSN}: 0144-8617
{Keywords}: Hohenbuehelia serotina; Polysaccharide; Antioxidant activity; Immunomodulation activity; Radioprotective effect
{Abstract}: This study was designed to investigate the antioxidant, immunomodulation and radioprotective activities of the polysaccharides from Hohenbuehelia serotina (HSP) against the damages induced by 60Co-radiation in vivo. Antioxidant results showed that the mice treated with HSP could effectively increase the superoxide dismutase (SOD) and catalase (CAT) activities, and reduce the malondialdehyde (MDA) level after 6 Gy irradiation compared to irradiated, non-treated controls. Administration with HSP (200 mg/kg BW) significantly promote the proliferation of splenocytes (p < 0.01), and prevent the number of the blood WBC decrease and the function of hematopoietic decline which caused by irradiation in whole blood. HSP displayed strong immunomodulation activity in vivo, and the effect was further verified by the assay of monocyte phagocytosis. In addition, HSP significantly inhibit irradiation-induced spleen cells arrest into G0/G1 phase. These results suggested that HSP exerts an effective protection against radiation-induced injury by improving the antioxidant and immunomodulation activities.

{Reference Type}: Journal Article
{Author}: Košťálová, Zuzana; Hromádková, Zdenka; Ebringerová, Anna; Polovka, Martin; Michaelsen, Terje Einar; Paulsen, Berit Smestad
{Year}: 2013
{Title}: Polysaccharides from the Styrian oil-pumpkin with antioxidant and complement-fixing activity
{URL}: http://www.sciencedirect.com/science/article/pii/S0926669012002191
{Tag}: 0
{Star}: 0
{Journal}: Industrial Crops and Products
{Volume}: 41
{Pages}: 127-133
{Date Displayed}: 2013/1//
{Alternate Title}: Industrial Crops and Products
{ISBN/ISSN}: 0926-6690
{Keywords}: Oil-pumpkin; Pectin; Structure; Antioxidant; Immunomodulatory activity
{Abstract}: Pectic polysaccharides have attracted great attention due to their health-promoting potential. From the Styrian oil-pumpkin biomass representing an alternative pectin source, two series of acidic polysaccharide fractions were isolated using in succession hot water, EDTA and dilute HCl. Chemical and spectroscopic (FTIR, NMR) analyses of the fractions revealed the predominance of partially methylesterified and acetylated pectins containing homogalacturonan and ramified rhamnogalacturonan elements, and a minority of phenolic compounds, protein and hemicelluloses. The pectins exhibited moderate antioxidant activities tested by colorimetric DPPH and FRAP assays and EPR method. The activities correlated with the total phenolic content. In the complement-fixing test, most of the pectin fractions exhibited potent effects comparable to the positive control – a pectin from Plantago major. The oil-pumpkin pectins represent potential antioxidant and immunoenhancing additives applicable in food and nutraceuticals.

{Reference Type}: Journal Article
{Author}: Wang, Yali; Zhao, Yu; Andrae-Marobela, K.; Okatch, H.; Xiao, Jianbo
{Year}: 2013
{Title}: Tea polysaccharides as food antioxidants: An old woman’s tale?
{URL}: http://www.sciencedirect.com/science/article/pii/S030881461201638X
{Tag}: 0
{Star}: 0
{Journal}: Food Chemistry
{Volume}: 138
{Issue}: 2–3
{Pages}: 1923-1927
{Date Displayed}: 2013/6/1/
{Alternate Title}: Food Chemistry
{ISBN/ISSN}: 0308-8146
{Keywords}: Tea; Polysaccharides; Antioxidants; EGCG; Free radical scavenging
{Abstract}: The crude polysaccharides from tea leaves (TPS) looks like have good antioxidant activities. However, whether or not the antioxidant abilities of crude TPS depend on tea polyphenols in the crude TPS is not understand. Herein, TPS fractions were isolated from crude TPS and their antioxidant activities were compared. The crude TPS showed stronger antioxidant activities than that of TPS fractions. However, EGCG (6.15 μg/mL) significantly enhanced DPPH radical scavenging potential of TPS fractions for each dose. Moreover, EGCG (8.0 μg/mL) significantly improved the reducing power of TPS fractions. EGCG causes a synergistic increase in the antioxidant activities of TPS fractions. The antioxidant activities of dextrans in the absence and presence of EGCG were investigated to illustrate that the antioxidant activities of TPS is similar to dextrans. These results illustrated that TPS fractions hardly exhibited antioxidant activities and tea polyphenols are the major antioxidant in the crude TPS. TPS as food antioxidants is an old woman’s tale.